Fig. 5: Correlation of peripheral blood NLR with tNLR.
From: Clinical implications of systemic and local immune responses in human angiosarcoma
a, b Peripheral blood NLR showed a positive correlation with intra-tumoral neutrophil-to-lymphocyte (tNLR) as derived from NanoString transcriptomic profiling (Spearman’s rho = 0.450, p = 0.0067), and correlated appropriately with corresponding cell-type scores. c Tumor-infiltrating immune cells were visualized via Multiplex Immunohistochemistry/Immunofluorescence (mIHC/IF). The proportion of neutrophils (CD15+), macrophages (CD68+), cytotoxic T-cells (CD8+), and regulatory T-cells (FOXP3+) relative to tumor cells (ERG+) were obtained and correlated with tNLR scores. d The tNLR scores correlated directly with CD15+ cells (Spearman’s rho 0.398, p = 0.0198) and CD68+ cells (Spearman’s rho 0.515, p = 0.0018) on mIHC/IF.
