Fig. 2: Overview of mutational landscape. | npj Precision Oncology

Fig. 2: Overview of mutational landscape.

From: Characterization of evolution trajectory and immune profiling of brain metastasis in lung adenocarcinoma

Fig. 2: Overview of mutational landscape.

a Identified mutational landscape of primary lung adenocarcinoma lesions and matched brain metastases (BM). Top panel: the number of somatic mutations in each tumor. Three clinicopathological characteristics (age, sex, and smoking history) are presented below. Left panel: the frequency of listed driver genes. Middle panel: the matrix of mutations in a selection of frequently mutated genes. Columns represent samples. Right panel: the total number of patients harboring mutations in each gene. b Pearson Correlation Coefficients of CNVs between primary tumors and BMs in each case. c The percentages of shared (present in both primary and metastatic lesions) or private (present only in primary or metastatic lesions) mutations in each case. d Top 10 enriched pathways via KEGG pathway analysis in primaries and brain metastases. BM_M brain metastatic lesion, BM_P primary lesion.

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