Fig. 4: Phylogenetic tree of four cases with synchronous lymphatic and brain metastases. | npj Precision Oncology

Fig. 4: Phylogenetic tree of four cases with synchronous lymphatic and brain metastases.

From: Characterization of evolution trajectory and immune profiling of brain metastasis in lung adenocarcinoma

Fig. 4: Phylogenetic tree of four cases with synchronous lymphatic and brain metastases.

a–d phylogenetic tree of BM32, BM43, BM36, and BM37. For each panel, heatplot with different bars represents various distributions of identified mutations including somatic SNVs and CNVs. Fraction of ubiquitous identified mutations (trunk) and unique identified mutations (branch) reveal the phylogenetic relationship of BM_P, BM_L and BM_M within a single case. BM_P primary lesion, BM_L lymph node metastasis, BM_M brain metastatic lesion.

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