Fig. 3: Mechanisms of breast cancer progression mediated through intrinsic inflammasome activation.
From: Dynamic roles of inflammasomes in inflammatory tumor microenvironment
In breast tumor microenvironment, sCD44 and WNT ligand released by breast cancer cells induce secretion of IL-1β from macrophages. In addition, TGF-β produced by breast cancer cells and ATP released from dying tumor cells stimulate IL-1β secretion from dendritic cells, which promotes IL-13 production in CD4+ T cells. This promotes breast cancer progression and metastasis.
