Fig. 4: Mechanisms of CRC regulation mediated by extrinsic inflammasome activation.
From: Dynamic roles of inflammasomes in inflammatory tumor microenvironment
In colorectal tumor microenvironment, IL-1β derived from infiltrated neutrophils, macrophages, and dendritic cells enhances CRC progression through production of IL-6 and IL-17A from lamina propria, macrophages, and dendritic cells. On the other hand, NLRP3 in bone marrow cells, NLRC4 and NLRC6 in hematopoietic cells, and NLRC4 in colon epithelial cells play tumor suppressive roles in CAC development.
