Table 2 Regulation of inflammasomes by natural compounds.
From: Dynamic roles of inflammasomes in inflammatory tumor microenvironment
Natural compounds | Mechanisms | Ref. |
|---|---|---|
Curcumin | Reduced expression of NLRP3, inhibition of caspase-1 cleavage, and secretion of IL-1β | |
Curcumin | Inhibition IL-1β secretion in bone marrow-derived macrophages (BMDMs) by preventing K+ efflux, ROS generation, and cathepsin B release | |
Resveratrol | Inhibition of NLRP3 inflammasome via preventing assembly of ASC and NLRP3 on the mitochondria and ER | |
cis-resveratrol | Inhibition of IL-1β secretion by suppression of P2X7R and ROS production | |
Sulforaphane | Inhibition of Aβ1-42-induced caspase-1 dependent inflammasome activation via inhibition of STAT-1 phosphorylation and activation of the Nrf2/HO-1 signaling cascade | |
Sulforaphane | Reduced monosodium urate (MSU) crystal-induced IL-1β secretion in peritonitis model, and inhibited NLRP1b, NLRP3, NAIP5/NLRC4 and AIM2 inflammasomes in BMDMs |
