Table 1 Univariate and multivariate Cox analysis for PFS and OS in three cohorts.

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p-Value	HR	95% CI	p-Value
OS
MSK-GI cohort^a
GIPS (high vs. low)	0.37	0.23–0.58	<0.001	0.33	0.21–0.54	<0.001
TMB (high vs. low)	0.54	0.34–0.86	0.009	0.57	0.35–0.92	0.023
Janjigian and Pender cohort^b
GIPS (high vs. low)	0.51	0.27–0.98	0.042	0.07	0.01–0.39	0.002
MSI status (MSI-H vs. MSS)	0.38	0.09–1.60	0.188	0.16	0.03–0.82	0.028
TMB (high vs. low)	0.60	0.29–1.20	0.167	0.45	0.18–1.20	0.099
PD-L1 (positive vs. negative)	0.24	0.08–0.77	0.016	0.09	0.02–0.51	0.006
PUCH cohort^c
GIPS (high vs. low)	0.43	0.23–0.80	0.008	0.47	0.25–0.88	0.019
MSI status (MSI-H vs. MSS)	0.47	0.19–1.10	0.097	0.36	0.15–0.88	0.025
TMB (high vs. low)	0.45	0.22–0.93	0.032	0.34	0.16–0.71	0.004
PD-L1 (positive vs. negative)	1.00	0.47–2.20	0.986	1.23	0.55–2.75	0.617
PFS
Janjigian and Pender cohort^b
GIPS (high vs. low)	0.39	0.20–0.74	0.004	0.12	0.03–0.44	0.001
MSI status (MSI-H vs. MSS)	0.39	0.12–1.30	0.123	0.21	0.05–0.85	0.029
TMB (high vs. low)	0.45	0.22–0.91	0.026	0.37	0.15–0.93	0.035
PD-L1 (positive vs. negative)	0.17	0.05–0.64	0.008	0.10	0.02–0.46	0.004
PUCH cohort^c
GIPS (high vs. low)	0.42	0.25–0.71	0.001	0.42	0.24–0.72	0.002
MSI status (MSI-H vs. MSS)	0.44	0.22–0.90	0.025	0.33	0.16–0.70	0.004
TMB (high vs. low)	0.47	0.26–0.85	0.013	0.36	0.19–0.67	0.001
PD-L1 (positive vs. negative)	1.30	0.69–2.40	0.415	1.52	0.80–2.90	0.206

^aThe multivariate analysis in the MSK-GI cohort was adjusted for age, sex, cancer type, drug class, and metastasis.
^bThe multivariate analysis in the Janjigian and Pender cohort was adjusted for age, sex, and liver metastasis.
^cThe multivariate analysis in the PUCH cohort was adjusted for age, sex, and drug class.

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