Fig. 2: Visualization of the sensitivity analysis experiment. | npj Precision Oncology

Fig. 2: Visualization of the sensitivity analysis experiment.

From: Computer extracted gland features from H&E predicts prostate cancer recurrence comparably to a genomic companion diagnostic test: a large multi-site study

Fig. 2: Visualization of the sensitivity analysis experiment.

a The first five boundary layers of a sample region of interest. In this panel, tissue outside of the original annotation was replaced with white background for clarity. b Results of removing an increasing number of boundary layers from the annotations of the validation set patients. The bars depict the fraction of patients who were originally Histotyping low/high-risk who changed to high-/low-risk after removing a given number of boundary layers. The dots show the c-index and 95% CI of Histotyping based on scores calculated after removing boundary layers. These results suggest that Histotyping is robust to variation in pathologist judgment on tumor boundary.

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