Fig. 1: Results of GWAS survival analysis.
From: A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival
a Manhattan plot for survival analysis P values. All genetic variants were coded using an additive model. SNPs with a minor allele frequency >5%, imputation R2 > 0.8, and Hardy–Weinberg equilibrium P > 1×10−5 were included. b, c Regional association plots for rs34211819 in TNS3 and rs1143149 in SEPT7. The left-hand Y-axis shows −log10 transformation of the P-value of individual SNPs plotted against the chromosomal base-pair position with an expansion of 500 kb in the flanks of the SNP position. The right-hand Y-axis shows recombination rate estimated for European populations from HapMap Data Rel 22/phase II. d, e Kaplan–Meier survival curves for rs34211819 and rs1143149 in NSCLC patients by 0, 1, and 2 minor alleles. HRs, 95% CI and P values were derived from Cox proportional hazards regression models adjusted for covariates.
