Fig. 2: Genomic characteristics of endometrioid ovarian carcinoma subtypes defined by hormone receptor expression patterns. | npj Precision Oncology

Fig. 2: Genomic characteristics of endometrioid ovarian carcinoma subtypes defined by hormone receptor expression patterns.

From: Integrated molecular characterisation of endometrioid ovarian carcinoma identifies opportunities for stratification

Fig. 2: Genomic characteristics of endometrioid ovarian carcinoma subtypes defined by hormone receptor expression patterns.

a Mutant-allele tumour heterogeneity (MATH) genomic complexity score. b Total number of copy number alterations (CNAs). c Overall tumour mutation burden (TMB). Labelled P values represent comparison of PR-high (PR + /ER + , PR + /ER−) and PR-low (PR−/ER + , PR−/ER−) cases with a two-sided Mann Whitney-U test. For TMB analysis, statistical power to detect a difference between PR-high and PR-low was 0.78 using a two-sided Mann Whitney-U test, assuming exponential distribution and an effect size P(X < Y) of 0.667. PR, progesterone receptor; ER, oestrogen receptor.

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