Fig. 3: PARPis promote the activation of OC stromal fibroblasts in vivo. | npj Precision Oncology

Fig. 3: PARPis promote the activation of OC stromal fibroblasts in vivo.

From: PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer

Fig. 3

a The schematic diagram of subcutaneous tumor models evaluating the effect of Ola or Nira on OC stroma in vivo. b Representative images and weight quantification of subcutaneous tumors from mice (n = 8) bearing SKOV3, OVCAR8, HCC1937, and OV90 cells in the control and Ola or Nira-treated groups. c–f Representative photographs and quantification of Masson’s trichrome and picrosirius red staining showing the contents of stromal and collagen deposition in SKOV3, OVCAR8, HCC1937, and OV90 xenografts. Measures were taken from different samples (n = 8). Scale bar, 50 µm. g–j Representative IHC images and quantification of α-SMA in the Ola or Nira-challenged tumor stroma and the control stroma. Measurements were taken from distinct samples (n = 8). Scale bar, 50 µm. Data are expressed as mean ± s.e.m., *p < 0.05; **p < 0.01; ***p < 0.001.

Back to article page