Fig. 2: Hierarchy of tiers curated in TOPOGRAPH. | npj Precision Oncology

Fig. 2: Hierarchy of tiers curated in TOPOGRAPH.

From: Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology

Fig. 2

The definition of evidence tiers in TOPOGRAPH reflects the maturity of a drug in its development. Tiers T1, T2, and R1 are considered standard-of-care, whereas the remaining tiers are investigational. Therapy yet to be adequately studied for possible clinical activities are designated T4. BM biomarker; Ph2 phase 2 clinical trials, Ph3 phase 3 clinical trials, SOC standard of care.

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