Fig. 10: Comparison of mDETECT and CA15-3 detection.
From: A DNA methylation-based liquid biopsy for triple-negative breast cancer
The levels of mDETECT and CA15-3 were compared for patients in both Cohort 03 and CRB. The normal range of CA15-3 is up to 30 units per ml (red-dashed line) while the threshold for mDETECT is 2.5 positive probes (Solid green line). In the Cohort 03, eight patients that were negative for CA15-3 were positive as determined by mDETECT (orange circles). Similarly, five patients in the CRB cohort that were negative by CA15-3 were positive by mDETECT (orange circles). The mDETECT and CA15-3 levels were somewhat correlated with an R2-value of 0.225 for Cohort 03 and 0.238 for the CRB cohort (blue dashed lines).
