Fig. 2: HRD scar scores and HRDetect scores of the LUAD and LUSC WGS datasets. | npj Precision Oncology

Fig. 2: HRD scar scores and HRDetect scores of the LUAD and LUSC WGS datasets.

From: A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures

Fig. 2: HRD scar scores and HRDetect scores of the LUAD and LUSC WGS datasets.The alternative text for this image may have been generated using AI.

In both panels, the sample names are colored according to their genotypes: yellow—BRCA2 heterozygote mutant, red— BRCA2 homozygote mutant, blue – BRCA1 heterozygote mutant. a HRDetect scores calculated using the original, breast cancer whole-genome-based HRDetect weights by following the original article’s standardization and attribute-transformation strategies12. b The total sum of the genomic scar scores (HRD-LOH, LST, and ntAI) determined from the LUAD and LUSC whole cancer genome’s allele-specific copy-number profiles.

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