Table 1 Clinical and molecular features of patients.

From: Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis

Patient id

Age (years)

Histology

Radical prostatectomy and/or radiotherapy

Primary ADT

Number of therapies before CTC collection

Type of tp at time of CTC collection

Serum CGA and /or NSE

Serum PSA (ng/ml)

Presence of visceral metastasis

Number of TSG (no = 0, single = 1, double = 2, triple = 3)

10

79

Adeno-NE

No

Yes

2

Cisplatin etoposide

High

0.18

Yes

1

11

62

CRPC-Adeno

Yes

Yes

3

Abiraterone

Normal

165

No

0

12

69

Small cell

No

Yes

1

Cisplatin

High

0.01

Yes

2

26

68

Small cell

Yes

Yes

3

Aurora A kinase inhibitor

High

0.008

Yes

2

31

74

Adeno-NE

No

Yes

2

Carboplatin etoposide

High

1.39

Yes

3

33

68

CRPC-Adeno

Yes

Yes

4

Docetaxel

Normal

329

No

1

35

59

Adeno-NE

Yes

No

1

Cisplatin etoposide

High

0.98

No

2

36

70

Adeno-NE

Yes

Yes

5

Rovalpituzumab tesirine

High

0.06

Yes

1

37

58

CRPC-Adeno

No

Yes

2

Enzalutamide

Normal

27.2

No

0

38

79

Adeno-NE

Yes

Yes

1

Cisplatin etoposide

High

0.02

Yes

2

41

65

CRPC-Adeno

Yes

Yes

4

Enzalutamide

Normal

7.85

No

1

  1. Abbreviations. Adeno-NE adenocarcinoma with neuroendocrine differentiation, ADT androgen deprivation therapy, CGA chromogranin A, CRPC-Adeno castration-resistant prostate adenocarcinoma, CTC circulating tumor cell, NSE neuron-specific enolase, TSG tumor suppressor genes.