Fig. 2: Research core biopsy specimens are histologically concordant with clinical specimens and show expected cell subsets. | npj Precision Oncology

Fig. 2: Research core biopsy specimens are histologically concordant with clinical specimens and show expected cell subsets.

From: Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses

Fig. 2

a Histologic concordance of clinical and research core biopsy specimens. H&E staining of representative research core specimens (left) and the clinical core specimens (right), showing grade 2 invasive lobular carcinoma (Case 1; 20x magnification) and grade 2 invasive ductal carcinoma (Case 2, 10x magnification). b Workflow for the long-term storage and processing of fresh core biopsy specimens for multiple experimental applications. c Cell subsets identified in research core biopsies. Single-cell suspensions were generated from each research core, stained and sorted by flow cytometry, using EpCAM- and CD45-directed antibodies as markers of epithelial and immune cells, respectively.

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