Fig. 3: Genomic alterations associated with sensitivity toward MI-773.

a Volcano plot showing the mutated genes positively or negatively associated with the MI-773 Abs IC₅₀ values. x-axis, the difference between mean Abs IC₅₀ in wild type vs. mutated groups, y-axis: p-values in log₁₀ scale. Green dots: association with lower MI-773 Abs IC₅₀, red dots: with higher Abs IC₅₀ (two-sided Wilcoxon p-value < 0.05), grey dots: association not significant (p-value ≥ 0.05). b Boxplot of MI-773 Abs IC₅₀ in the TP53 wild type (WT TP53) and mutant (MUT TP53) groups. p-Value was obtained from the two-sided Wilcoxon test. Box limits are the 1st and 3rd interquartile; the inner horizontal line is the median, whiskers extend 1.5 times the interquartile range from the 1st and 3rd interquartile, data points were plotted as black dots. c The association between CL sensitivity to MI-773 and TP53 status. The upper panel shows a waterfall plot of the MI-773 Abs IC₅₀ of all 237 CLs. The lower panel shows the mutation status of the TP53 gene in the corresponding CLs. d Lollipop plot showing the location on p53 protein domains of the TP53 mutations identified on the 237-CL panel. Top: all TP53 mutations, bottom: mutations retrieved in more than one model (recurrent). The colours of the circles reflect the response classes to the MI-773.