Table 3 Association between high-risk scorea vs average risk scoreb and the outcome of incident diagnosis of any grade prostate cancer.
From: Prostate cancer polygenic risk score and prediction of lethal prostate cancer
Cohort | Risk score | Event N | Average score N | High score N | OR (95% CI) | p value |
|---|---|---|---|---|---|---|
MDC | PRACTICAL risk (145 SNPs) | 524 | 1898 | 69 | 3.35 (2.07, 5.46) | <0.001 |
MDC | Modified PRACTICAL risk | 554 | 1925 | 77 | 2.97 (1.88, 4.71) | <0.001 |
VIP | Modified PRACTICAL risk | 669 | 2525 | 82 | 5.99 (3.79, 9.66) | <0.001 |
Both | Modified PRACTICAL risk | 1223 | 4450 | 159 | 4.25 (3.09, 5.90) | <0.001 |
