Table 4 Association between high-risk scorea vs average risk scoreb and the outcome of incident diagnosis of any grade prostate cancer.

From: Prostate cancer polygenic risk score and prediction of lethal prostate cancer

Cohort

Risk score

Event N

Average score N

High score N

OR (95% CI)

p value

MDC

PRACTICAL risk (145 SNPs)

723

1898

527

2.35 (1.92, 2.87)

<0.001

MDC

Modified PRACTICAL risk

733

1925

503

2.12 (1.73, 2.59)

<0.001

VIP

Modified PRACTICAL risk

893

2525

673

2.19 (1.83, 2.61)

<0.001

Both

Modified PRACTICAL risk

1626

4450

1176

2.15 (1.88, 2.46)

<0.001

  1. aHigh-risk score is defined as 90–99th centile
  2. bAverage risk score is defined as 25–75th centile
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