Fig. 2: Predictivity of genomic scar signatures for deleterious BRCA1/2 alterations (H1a vs. H3).
From: Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)
a ROC analysis of seven genomic signatures. Significant positive associations are shown in heat colors (AUC > 0.5, FDR = 10%). Non-significant or negative associations are shown in grey. b–d ROC curves for the cancer types showing significant positive association with HRDsum, SBS3, and TMB. e Significantly enhanced levels of HRDsum in tumors with deleterious BRCA1/2 mutations (H1a vs. H3) in BRCA, BLCA, OV, SARC, and PRAD. In the pan-cancer analysis, HRDsum levels were significantly enhanced in classes H1a, H1b, H2a and H2b compared to H3. *P < 0.05, **P < 0.01, and ***P < 0.005.
