Fig. 4: Diagram representation of the alternative splicing pattern of GGA2 transcripts and the amino acid (aa) sequence, protein structures, and domains of the GGA2-isoforms.
From: Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk
a Results of SNP rs2285521 sequencing in the 53 bp sequence of 5’ UTR region in Exon 1 of the GGA2: Genomic structure of the GGA2-X1 and GGA2-X2. Splicing pattern of the GGA2 variant with SNP rs2285521 T>C. The position of the A nucleotide in the start codon (ATG) is defined as +1. b Part of RNA secondary structure of the GGA2 rs2285521 U and GGA2 rs2285521 C. c The aa sequence of GGA2-X1 and GGA2-X2. The GGA2-X1 isoform encodes a 576 aa protein and GGA2-X2 encodes a 526 aa protein. The aa sequence of red is where GGA2-X2 starts. d Part of the secondary structures and domains of putative isoforms of GGA2-X1 and GGA2-X2. aa1-aa50 circled by red was the part two isoforms differed.
