Fig. 2: Tumor Mutational Burden (TMB) (mutations per megabase) in primary BRCA2-deficient and BRCA2-intact tumor samples.
From: The tumor mutational landscape of BRCA2-deficient primary and metastatic prostate cancer
Panels display a the distribution of total TMB in all tumors, b the distribution of total TMB by BRCA2 status, c the distribution of pathogenic TMB in all tumors, and d the distribution of pathogenic TMB by BRCA2 status. TMB is estimated from samples with whole genome sequencing from the ICGC dataset (n = 531). In panels b and d, the lower, middle, and upper lines correspond to the lower quartile, median, and upper quartile of TMB, respectively. P-values are from a two-sided Wilcoxon rank-sum test. BRCA2d BRCA2-deficient; BRCA2i BRCA2-intact.
