Fig. 2: SBRT dose-dependent effects on CD8⁺ and CD4⁺ circulating T-cell proliferation post-treatment in early-stage NSCLC patients.

a Fraction and absolute peripheral blood cell numbers of Ki-67⁺CD8⁺ and Ki-67⁺CD4⁺ T-cells after SBRT using doses of ≤10 Gy (left) versus >10 Gy (right). b Fraction and absolute peripheral blood cell numbers of Ki-67⁺PD-1⁺ versus Ki-67⁺PD-1⁻ CD8⁺ and CD4⁺ T-cells after SBRT using doses of ≤10 Gy. c Fraction and absolute peripheral blood cell numbers of Ki-67⁺PD-1⁺/ Ki-67⁺PD-1⁻ CD8⁺ and CD4⁺ T-cells with SBRT using doses >10 Gy. *p ≤ 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 from mixed effects model for repeated measures with Geisser-Greenhouse correction and Benjamini, Krieger, and Yekutieli for the false discovery rate, two-sided. Arrows indicate the direction of change. Data are shown as median values (center lines) and interquartile ranges.