Fig. 5: ScarHRD values compared to DARC sign BRCA2d probabilities.
From: A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes
a Homologous Recombination Deficiency - Loss of Heterozygosity (HRD-LOH) score: the number of regions greater than 15 Mb (but not covering the entire chromosome) that show LOH. b Large Scale Transition (LST) score: the number of chromosomal breaks between adjacent regions of at least 10 Mb, with a distance between them not larger than 3 Mb. c Telomeric Allelic Imbalances (TelomericAI) score, the number of allelic imbalances that extend to the telomeric end of a chromosome. d Sum of scarHRD calculated values. P-value test statistics are from Mann–Whitney U tests. Cohen’s D is the standardised mean difference.
