Fig. 5: Associations between polygenic risk scores and breast cancer-specific survival.
From: Development and testing of a polygenic risk score for breast cancer aggressiveness
Cox proportional hazards models were constructed for: the polygenic risk score weighted on risk of recurrence (ROR-P PRS), the polygenic risk score for risk of estrogen-negative versus positive breast cancer (ROR-P PRSER-/ER+), and ROR-P PRS adjusted for the effects of PRSER-/ER+ in a joint model. All models were adjusted for genetic ancestry (principal components 1–10). Hazard ratios per standard deviation are shown for UK Biobank, the Pathways Study, and the combined studies using random effects meta-analysis.
