Fig. 3: ALDH1A1 promotes the POLQ/Polθ expression by increasing the production of RA. | npj Precision Oncology

Fig. 3: ALDH1A1 promotes the POLQ/Polθ expression by increasing the production of RA.

From: ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression

Fig. 3

a PEO1, OVCAR3, and Kuramochi cells were treated with ATRA for 48 h, immunoblotting was conducted to determine the expression of Polθ. The relative amounts of Polθ were listed under the corresponding band. b, c PEO1 (b) and Kuramochi (c) cells were transfected with ALDH1A1 or/and CYP26A1 for 48 h, qRT-PCR was conducted to determine the mRNA level of ALDH1A1, CYP26A1, and POLQ. Measurements were taken from distinct samples. N = 3, bar: s.d., **P < 0.01.

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