Fig. 5: Gleason grading: agreement analysis between pathologists and AI tool. | npj Precision Oncology

Fig. 5: Gleason grading: agreement analysis between pathologists and AI tool.

From: An international multi-institutional validation study of the algorithm for prostate cancer detection and Gleason grading

Fig. 5

Two datasets of tumor-containing biopsy slides were used for this analysis (consecutive cases from UKK-2 and WNS A cohorts). Quadratically weighted kappa statistics was used for calculation of agreement. Presented are comparisons between single graders (UKK: 10 board-certified pathologists and AI tool; WNS: 11 board-certified pathologists and AI tool) as well as average quadratically weighted kappa levels for single graders. Pathologists 1 and 9 (P01 and P09) are general surgical pathologists working routinely with prostate cases. All other pathologists are experienced genitourinary pathologists. AI Tool performs on par with pathologists. For distribution of Gleason grade groups in cohorts see Fig. 6a. a Cohort UKK. b Cohort WNS.

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