Table 3 The comparison of immunohistochemistry, DNA-, and RNA-based NGS assays.
From: Prevalence and clinico-genomic characteristics of patients with TRK fusion cancer in China
Patient | Tumor_type | Fusion at DNA level | NGS RNA-seq | NGS DNA-seq | IHC |
|---|---|---|---|---|---|
2 | Infantile fibrosarcoma | ETV6 exon1-5-NTRK3 exon15–19 | Positive | Positive | Negative |
5 | Cellular plexiform schwannoma | TPM3 exon1-10-NTRK1 exon9–17 | Positive | Positive | Positive |
7 | Rhabdomyosarcoma | LMNA exon1-5-NTRK1 exon8–17 | Positive | Positive | Positive |
8 | Infantile fibrosarcoma | TPM3 exon1-9-NTRK1 exon9–17 | Positive | Positive | /a |
9 | Soft tissue sarcoma of the abdomen | LMNA exon1-2-NTRK1 exon10–17 | Positive | Positive | / |
10 | Soft tissue sarcoma of the abdomen | LMNA exon1-2-NTRK1 exon11–17 | Positive | Positive | Positive |
11 | Mucoepidermoid carcinoma of trachea | C7orf69 exon1-3-NTRK3 exon15–19 | Negative | Positive | / |
12 | Spindle cell sarcoma of the prostate | RBPMS exon1-5-NTRK3 exon14–19 | Positive | Positive | / |
13 | Prostatic stromal tumor | IRF2BP2 exon1-NTRK1 exon17 | Positive | Positive | Positive |
15 | Spindle cell sarcoma of the thigh | LMNA exon1-2-NTRK1 exon11–17 | Positive | Positive | Positive |
17 | Spindle cell tumors of the sacrum | LMNA exon1-2-NTRK1 exon11–17 | Positive | Positive | Positive |
29 | Colorectal_cancer | TPM3 exon1-7-NTRK1 exon9–17 | Positive | Positive | Positive |
38 | Colorectal_cancer | TPR exon1-21-NTRK1 exon11–17 | Positive | Positive | Negative |
