Table 2 Clinicogenomic Characteristics Of The CGP Cohort.
Characteristic | All Cases N = 125,128 | PPGV+ Cases N = 12,176 | PPGV- Cases N = 112,952 | P-Value (FDR) | |||
|---|---|---|---|---|---|---|---|
n | % | n | % | n | % | ||
Age At Bx, Median (Q1, Q3) | 66 (58, 74) | 65 (57, 73) | 67 (58, 74) | < 0.001 | |||
≤ 50 Years | 14,452 | 11.8% | 1652 | 13.8% | 12,800 | 11.5% | < 0.001 |
Unknown | 2313 | - | 212 | - | 2101 | - | - |
Sex | < 0.001 | ||||||
Female | 64,885 | 51.9% | 6730 | 55.3% | 58,155 | 51.5% | - |
Male | 60,243 | 48.1% | 5446 | 44.7% | 54,797 | 48.5% | - |
Predicted Ancestry | < 0.001 | ||||||
European | 93,844 | 75.1% | 9633 | 79.2% | 84,211 | 74.6% | ‡ |
African | 14,646 | 11.7% | 1126 | 9.3% | 13,520 | 12.0% | ‡ |
Admixed American | 11,132 | 8.9% | 943 | 7.8% | 10,189 | 9.0% | ‡ |
East Asian | 4148 | 3.3% | 360 | 3.0% | 3788 | 3.4% | - |
South Asian | 1214 | 1.0% | 98 | 0.8% | 1116 | 1.0% | - |
Unknown | 144 | - | 16 | - | 128 | - | - |
Tumor Bx Site | < 0.001 | ||||||
Local | 47,643 | 43.6% | 4860 | 46.2% | 42,783 | 43.3% | ‡ |
Metastatic | 27,103 | 24.8% | 2976 | 28.3% | 24,127 | 24.4% | ‡ |
Lymph Node | 8941 | 8.2% | 935 | 8.9% | 8006 | 8.1% | ‡ |
Peripheral Blood | 25,584 | 23.4% | 1739 | 16.5% | 23,845 | 24.1% | ‡ |
Unspecified | 15,857 | - | 1666 | - | 14,191 | - | - |
MSI-H | 2562 | 2.0% | 1432 | 11.8% | 1130 | 1.0% | < 0.001 |
TMB ≥ 10 Mut/Mb1 | 16,709 | 16.8% | 3200 | 30.7% | 13,509 | 15.2% | < 0.001 |
bTMB ≥ 10 Mut/Mb2 | 2832 | 16.5% | 215 | 18.3% | 2617 | 16.4% | 0.09 |
