Table 2 Summary of deregulated pathways.
A. Metabolic pathways upregulated in pre-chemotherapy tissues from ER and PR tumors. | |||
|---|---|---|---|
Upregulated pathways in chemo-naïve tissues of ER versus PR | |||
ER | PR | ||
Stroma | Epithelium | Stroma | Epithelium |
Pyrimidine salvage (entities ratio 0.01) | Respiratory electron transporta (entities ratio 0.008) | Transport of bile salts and organic acids metal ions and amine compoundsa (entities ratio 0.04) | Recycle of bile acids and salts (entities ratio 0.01) |
Metabolism of amino acids and derivatives (entities ratio 0.15) | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alphaa (entities ratio 0.003) | Pyrimidine salvage (entities ratio 0.01) | |
Pyrimidine catabolism (entities ratio 0.02) | |||
B. Metabolic pathways upregulated and downregulated in post- versus pre-chemotherapy tissues from ER and PR tumors. | ||||
|---|---|---|---|---|
Deregulated pathways in post-chemo versus pre-chemo tissues of ER and PR | ||||
ER | PR | |||
Stroma | Epithelium | Stroma | Epithelium | |
Upregulated | Urea cycle (entities ratio 0.12) | TP53 Regulates Metabolic Genes (entities ratio 0.01) | Aspartate and asparagine metabolism (entities ratio 0.01) | TP53 Regulates Metabolic Gene (entities ratio 0.01) |
Citric acids cycle (entities ratio 0.02) | Metabolism of nucleotides (entities ratio 0.08) | Phenylalanine and tyrosine metabolism (entities ratio 0.02) | Metabolism of nucleotides (entities ratio 0.08) | |
Nucleotide biosynthesis (entities ratio 0.03) | ||||
Urea cycle (entities ratio 0.01) | ||||
Downregulated | Metabolism of nucleotidesb (entities ratio 0.08) | Urea cycleb (entities ratio 0.01) | GABA degradation and synthesis (entities ratio 0.01) | 2-Hydroxyglutarate |
Nucleotide salvageb (entities ratio 0.03) | Metabolism of nucleotidesb (entities ratio 0.08) | |||
Purine catabolismb (entities ratio 0.03) | Phenylalanine and tyrosine metabolismb (entities ratio 0.02) | |||
