Fig. 6: Administration of cetuximab rescues cisplatin efficacy against tumor growth in mice that were subcutaneously co-injected with FaDu cells and rCAFs. | npj Precision Oncology

Fig. 6: Administration of cetuximab rescues cisplatin efficacy against tumor growth in mice that were subcutaneously co-injected with FaDu cells and rCAFs.

From: Chemoresistant fibroblasts dictate neoadjuvant chemotherapeutic response of head and neck cancer via TGFα-EGFR paracrine signaling

Fig. 6

a Representative gross tumor image from each treatment group is given. b Line graphs show the tumor growth in each treatment group (n = 5 mice per group). Bar chart represent the mean of final tumor weight (c) or volume (d) in each group. Data are shown as means ± S.E.M. e IHC analysis of p-EGFR, p-p53, cleaved caspase-3 and Ki67 staining in tumor sections derived from each treatment group (n = 5 tumors analyzed per group). Bar charts represent the quantification of staining intensity in each group. Data are shown as means ± S.E.M. *P < 0.05, **P < 0.01, ***P < 0.001, N.S. non-significant. b Two-way ANOVA. c–e One-way ANOVA. Scale bars in (a) represent 1 cm, (e) 100 μm.

Back to article page