Fig. 4: Differentially expressed genes in MBM compared to PCM and ECM. | npj Precision Oncology

Fig. 4: Differentially expressed genes in MBM compared to PCM and ECM.

From: Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases

Fig. 4

Ingenuity pathway analysis (IPA) shows a significant enrichment of pathways in MBM compared to ECM (a) and PCM (b). Orange node, enrichment in MBM; blue node, enrichment in ECM or PCM. c Differentially expressed genes (Log2FC; adjusted p < 0.01) in MBM compared to PCM. Only genes that were differentially expressed in MBM compared to both PCM and ECM are shown. Orange bars indicate genes that were upregulated in MBM and blue bars indicate genes that were downregulated in MBM.

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