Fig. 5: Surgical tumor mapping workflow transforms histological findings into patient-tailored, surgeon-drawn surgical tumor maps in correct anatomical location/orientation for real-time surgical recommendations.

Mapping margin assessment results to surgical tumor map via Mapping Pane: representation of workflow using three separate sections, the first (a) from one case, and the second two (b, c) are serial sections in another case; first, margins are assessed via Histology Pane and tissue orientation and tumor localization results are plotted over the WSI; then, results are mapped to surgical tumor diagram selected by the user (a features top of scalp, while case b, c are of front of face), where circle is drawn by user to represent surgical site anatomic location and an arbitrary orientation is defined via user drawing of blue/red lines. Note how tumor results are morphed and rotated to match circle interior and orientation in surgical tumor maps, where density map in surgical tumor map represents tumor at user defined threshold. For b, c, note how tumor is automatically rotated close to 180 degrees to preserve orientation of margin on surgical map.