Fig. 6: FGFR2c expression relative to Peptidylprolyl isomerase B (PPIB) a housekeeping gene following FGFR2 shRNA mediated knockdown in four endometrial cancer PDXO models. | npj Precision Oncology

Fig. 6: FGFR2c expression relative to Peptidylprolyl isomerase B (PPIB) a housekeeping gene following FGFR2 shRNA mediated knockdown in four endometrial cancer PDXO models.

From: Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

Fig. 6: FGFR2c expression relative to Peptidylprolyl isomerase B (PPIB) a housekeeping gene following FGFR2 shRNA mediated knockdown in four endometrial cancer PDXO models.The alternative text for this image may have been generated using AI.

a Representative micrography images of FGFR2c mRNA expression (first, third and fourth column) and PPIB a housekeeping gene (second and fifth column) detected via BaseScope RNA ISH on indicated endometrial PDXO models. b Analyses showing FGFR2c RNA ISH signals relative to PPIB (a housekeeping gene) in four endometrial cancer PDXOs. BaseScope RNA ISH was performed on FFPE organoid blocks collected 6 days after antibiotic selection. The scale bar indicates 50 µm. EX Exon, FFPE Formalin fixed paraffin embaded, FGFR2c Fibroblast growth factor receptor 2c splice isoform, NT nontargeting; PDXO Patient-derived xenograft organoids, PPIB Peptidylprolyl isomerase B.

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