Fig. 4: SPP1+ macrophage (Macro_SPP1) expressed metalloproteinases, and regulated by HIF1A. | npj Precision Oncology

Fig. 4: SPP1+ macrophage (Macro_SPP1) expressed metalloproteinases, and regulated by HIF1A.

From: Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma

Fig. 4

a The proportion of six clusters (epithelial cells, myeloid cells, fibroblasts, endothelial cells, T cells, and B cells) in the CSC-high and CSC-low groups. b UMAP plots showing myeloid cell subtypes in the CSC-high and CSC-low groups, including DC, monocyte, Macro_SPP1, MRC1+ macrophage (Macro_MRC1), adipogenic macrophage (Macro_adipo), and proliferating macrophage (Macro_prolif). The red circle encompassed Macro_SPP1. c Top 5 upregulated and downregulated genes of six subclusters. d Bar chart displaying the up-regulated and down-regulated pathways in Macro_SPP1. e Expression patterns of the most varied transcription factors (TFs) in Macro_SPP1. (f) Distribution of Macro_SPP1 in normal and HCC tissues. g Distribution of Macro_SPP1 in early and advanced stage HCC tissues. h HCC patients with higher infiltration of Macro_SPP1 exhibited shorter overall survival (OS). (i) The non-responders exhibited higher Macro_SPP1 compared to responders in HCC patients treated with immunotherapy.

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