Fig. 7: SPP1 signaling in cell-cell communication. | npj Precision Oncology

Fig. 7: SPP1 signaling in cell-cell communication.

From: Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma

Fig. 7

a The cell-cell communication between CSC and Macro_SPP1 at the single-cell level. b The role of cluster 3 in the cell-cell communication in the tumor boundary area of cluster 3. (c) The outgoing pattern of the CNV clusters in the tumor boundary area of cluster 3. d The SPP1 signaling pathway network in the tumor boundary area of cluster 3. e The ligand-receptor pairs in SPP1 signaling pathway signaled by cluster 3 to all clusters.

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