Table 1 Entire cohort of 241 pediatric brain tumor samples, including 155 tumors and 86 derived cell cultures, and comparison between the initial histopathological assessment and the results of the brain tumor classifier (v12.5)

From: Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling

Tissues

Cells

Histopathological assessment

Samples

Paired with cells

Only tissues

Tot

Faithful + Useful (%)

Paired with tissues

Only cells

Organoids

Commercial

Tot

Faithful + Useful (%)

MB

82

5

56

61

61 (100)

8

0

9

4

21

15 (71)

LGG

67

13

32

45

43 (95)

20

2

0

0

22

3 (14)

HGG

39

8

15

23

23 (100)

15

1

0

1

17

5 (29)

DMG

37

6

7

13

13 (100)

11

13

0

0

24

16 (67)

EPN

11

2

7

9

9 (100)

2

0

0

0

2

2 (100)

MNG

4

0

4

4

4 (100)

0

0

0

0

0

0

TOTAL

241

34

121

155

153 (99)

56

16

9

5

86

41 (48)

  1. For each pediatric brain tumor category (tissues and cells), the proportion of classifier results that match histopathological data is reported. Faithful: classifier score > 0.84; Useful: classifier score between 0.3 and 0.84.
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