Fig. 1: Single-cell transcriptomic analysis in PDAC discovery cohort. | npj Precision Oncology

Fig. 1: Single-cell transcriptomic analysis in PDAC discovery cohort.

From: Multiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer

Fig. 1: Single-cell transcriptomic analysis in PDAC discovery cohort.The alternative text for this image may have been generated using AI.

a Overall design and workflow of experiment in this study; b UMAP reduced plot characterizing the integrated cell map, consisting of 13 annotated cell types together with representative marker genes; c The regulation of genes of NET signature in tumor samples. The dotted dashed line indicated p = 0.01; d NMF reduction of neutrophils. Three subtypes defined by NET signature were highlighted and the expression of their representative genes (IL1B, PDE4B, and TLR2) was shown on the right side.

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