Fig. 4: Characteristics of CXCL13⁺ CD8⁺ TRMs.

a tSNE plot showing the distribution of CXCL13⁺ CD8⁺ TRMs (red) relative to that of the other TRM subclusters (blue). b Volcano plot depicting DEGs between CXCL13⁺ CD8⁺ TRMs (red) and the other TRM subclusters (blue). c GO term analysis of CXCL13⁺ CD8⁺ TRMs. The color intensity indicates p-value magnitude. d Violin plots illustrating the expression of the indicated genes in CXCL13⁺ CD8⁺ TRMs and the other TRM subclusters. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 (two-sided Wilcoxon test). e GSEA showing differences in pathway activity between CXCL13⁺ CD8⁺ TRMs and the other TRM subclusters. f Volcano plot depicting the DEGs between CXCL13⁺ CD8⁺ TRMs from CC tissues (red) and those from normal cervical tissues (blue). g Violin plots displaying the expression of the indicated genes in CXCL13⁺ CD8⁺ TRMs from CC tissues and in those from normal cervical tissues. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 (two-sided Wilcoxon test). h GO term analysis of CXCL13⁺ CD8⁺ TRMs from CC tissues; color intensity indicates p-value magnitude. i GSEA results showing differences in the pathway activities of CXCL13⁺ CD8⁺ TRMs from CC tissues and those from normal cervical tissues. j Kaplan–Meier survival analysis of patients with CC following radiotherapy from TCGA database, stratified based on high or low signature gene set score of CXCL13⁺ CD8⁺ TRMs. The p-values were calculated using the two-sided log-rank test.