Fig. 5: Characteristics of PLAC8⁺ CD8⁺ TRMs.

a tSNE plot showing the distribution of PLAC8⁺ CD8⁺ TRMs (red) relative to that of the other TRM subclusters (blue). b Volcano plot showing DEGs between PLAC8⁺ CD8⁺ TRMs (red) and the other TRM subclusters (blue). c Violin plots displaying the expression of the indicated genes between PLAC8⁺ CD8⁺ TRMs and the other TRM subclusters. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 (two-sided Wilcoxon test). d GO term analysis of PLAC8⁺ CD8⁺ TRMs; the color intensity indicates p^-value magnitude. e Violin plots showing differences in pathway activity between PLAC8⁺ CD8⁺ TRMs (red) and the other TRM subclusters (blue). f Volcano plot showing DEGs in PLAC8⁺ CD8⁺ TRMs between CC tissues (red) and normal cervical tissues (blue). g Violin plots illustrating the expression of indicated genes in PLAC8⁺ CD8⁺ TRMs between CC tissues and normal cervical tissues. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 (two-sided Wilcoxon test). h GO term analysis in PLAC8⁺ CD8⁺ TRMs of CC tissues. The intensity of color indicates p-values. i GSEA showing differences in the pathway activities of PLAC8⁺ CD8⁺ TRMs from CC tissues and those from normal cervical tissues. j Kaplan–Meier survival analysis of patients with CC following radiotherapy from TCGA database, stratified based on high or low signature gene set score of PLAC8⁺ CD8⁺ TRMs. The p-values were calculated using a two-sided log-rank test.