Table 2 Association between infiltrated metLN patterns and patients’ clinicopathological features

From: Prognostic patterns in invasion lymph nodes of lung adenocarcinoma reveal distinct tumor microenvironments

Clinicopathological variables

Case

Infiltrated pattern

χ2

p-value

Polarized

Scattered

Gender

Male

161

142

19

4.169

0.041*

 

Female

151

143

8

  

Age

≤60

158

142

16

0.878

0.349

 

>60

154

143

11

  

Smoke

Ever

92

78

14

7.110

0.008*

 

Never

220

207

13

  

Tumor size

≤3 cm

160

150

10

2.401

0.121

 

>3 cm

152

135

17

  

Tumor location

RUL

86

80

6

7.055

0.133

 

RML

36

33

3

  
 

RLL

56

47

9

  
 

LUL

80

77

3

  
 

LLL

54

48

6

  

Driver mutation

EGFR

151

141

10

4.525

0.210

 

KRAS

34

29

5

  
 

FUSION

41

35

6

  
 

Wild-type

86

80

6

  

Vascular invasion

Absent

194

182

12

3.953

0.047*

 

Present

118

103

15

  

pStage N

N1

164

155

9

4.384

0.036*

 

N2

148

130

18

  

Primary tumor pathological classification (WHO)

Acinar

148

137

11

0.890

0.828

 

Papillary

70

64

6

  
 

Solid

61

55

6

  
 

Micropapillary

33

29

4

  

Metastatic LN pathological classification (WHO)

Acinar

118

112

6

6.751

0.080

 

Papillary

75

69

6

  
 

Solid

96

82

14

  
 

Micropapillary

23

22

1

  

LNR status

Low (<0.33)

206

196

10

11.073

0.001*

 

High (>0.33)

106

89

17

  
  1. *Statistical significance determined by χ2 (chi-square) test (p < 0.05).