Table 3 Association between compositional TDLNs+ patterns and patients’ clinicopathological features

Clinicopathological variables		Case	Compositional pattern				χ²	p-value
Clinicopathological variables		Case	Colloid	Necrosis	Specific	Common	χ²	p-value
Gender	Male	161	58	26	8	69	0.752	0.861
Gender	Female	151	53	21	6	71
Age	≤60	158	49	26	9	74	3.604	0.308
Age	>60	154	62	21	5	66
Smoke	Ever	92	36	15	4	37	1.232	0.745
Smoke	Never	220	75	32	10	103
Tumor size	≤3 cm	160	54	19	6	81	5.346	0.148
Tumor size	>3 cm	152	57	28	8	59
Tumor location	RUL	86	24	19	3	40	26.003	0.011^*
	RML	36	17	4	1	14
	RLL	56	17	2	3	34
	LUL	80	34	14	7	25
	LLL	54	19	8	0	27
Driver mutation	EGFR	151	68	18	5	60	14.542	0.104
	KRAS	34	8	5	2	19
	FUSION	41	10	6	2	23
	Wild-type	86	25	18	5	38
Vascular invasion	Absent	194	68	24	8	94	4.127	0.248
Vascular invasion	Present	118	43	23	6	46
pStage N	N1	164	61	17	5	81	8.488	0.037^*
pStage N	N2	148	50	30	9	59
Primary tumor WHO classification	Acinar	148	49	18	8	73	9.921	0.357
	Papillary	70	32	8	2	28
	Solid	61	20	13	2	26
	Micropapillary	33	10	8	2	13
Metastatic LN WHO classification	Acinar	118	49	13	2	54	21.21	0.012*
	Papillary	75	18	12	2	43
	Solid	96	37	19	9	31
	Micropapillary	23	7	3	1	12
LNR status	Low (<0.33)	206	67	24	6	109	18.365	<0.001^*
	High (>0.33)	106	44	23	8	31

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