Table 4 Univariable and multivariable analysis for variables affecting disease-free survival

Gender

Male

Ref.

Ref.

Female

0.89

0.622

1.40

0.324

Age

≤60

Ref.

Ref.

>60

0.85

0.503

0.71

0.180

Smoke

Never

Ref.

Ref.

Ever

1.49

0.086

1.72

0.158

Tumor size

≤3 cm

Ref.

Ref.

>3 cm

1.59

0.041*

1.24

0.380

Tumor location

LLL

Ref.

Ref.

RUL

1.61

0.172

1.82

0.134

RML

1.36

0.471

1.75

0.233

RLL

0.65

0.333

0.62

0.305

LUL

0.74

0.460

0.56

0.212

Driver mutation

EGFR

Ref.

Ref.

KRAS

1.04

0.911

1.09

0.857

FUSION

1.07

0.840

1.62

0.236

WT

1.14

0.611

1.26

0.441

Vascular invasion

Absent

Ref.

Ref.

Present

1.90

0.005^*

1.79

0.030^*

pStage N

N1

Ref.

Ref.

N2

2.04

0.002^*

1.73

0.047^*

Infiltrated pattern

Polarized

Ref.

Ref.

Scattered

2.03

0.036^*

2.37

0.035^*

Compositional pattern

Common

Ref.

Ref.

Colloid

1.78

0.036^*

1.95

0.038^*

Necrosis

2.94

<0.001^*

2.21

0.020^*

Specific

2.48

0.025^*

1.97

0.142

Primary tumor pathological classification (WHO)

Acinar

Ref.

Ref.

Papillary

1.00

0.980

0.81

0.578

Solid

1.91

0.027*

1.36

0.362

Micropapillary

2.31

0.007*

1.98

0.071

Metastatic LN pathological classification (WHO)

Acinar

Ref.

Ref.

Papillary

0.82

0.570

0.92

0.836

Solid

1.65

0.053

1.01

0.958

Micropapillary

1.21

0.668

1.93

0.195

LNR status

Low (<0.33)

Ref.

Ref.

High (>0.33)

2.43

<0.001^*

1.84

0.028^*