Fig. 2: Expression of genes involved in antigen processing. | npj Precision Oncology

Fig. 2: Expression of genes involved in antigen processing.

From: Peptide-stimulated T cells bypass immune checkpoint inhibitor resistance and eliminate autologous microsatellite instable colorectal cancer cells

Fig. 2

TCGA data of CRC (n = 484) were compared with normal colon tissue (TCGA: n = 51, GTEX: n = 308) and tumor cell lines (n = 2), regarding expression of 18 genes involved in antigen processing and presentation. Tumor cell line data contained three technical replicates each, but due to the small group size, statistical calculations were omitted. a Heatmap of analyzed data sets depicting high expression in blue and low expression in red, in regard to TMB. b Mean expression of antigen processing genes including standard deviation; t test of tumor sample vs. normal tissue with p < 0.05 (*), p < 0.01 (**) and p < 0.001 (***); t test of TMB high vs. TMB low with p < 0.05 (#), p < 0.01 (##) and p < 0.001 (###).

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