Fig. 5: Cytotoxicity of pTc HROC113. | npj Precision Oncology

Fig. 5: Cytotoxicity of pTc HROC113.

From: Peptide-stimulated T cells bypass immune checkpoint inhibitor resistance and eliminate autologous microsatellite instable colorectal cancer cells

Fig. 5

Tumor cells were incubated for 48 h with pTc HROC113, which were pre-stimulated for 14 days with tumor-specific cryptic or neoantigenic peptides. pTc HROC113 stimulated without peptide served as control. Medium was supplemented with three ICI (20 µg/ml pembrolizumab, 10 µg/ml ipilimumab and 20 µg/ml durvalumab) and/or 400 µmol PI-9i. (*) p < 0.05 and (**) p < 0.005 in t test of sample and unstimulated control without immune modulators. Depicted are means with standard deviation of three biologically replicates.

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