Table 3 Univariable and multivariable analyses of bone metastasis-free survival in patients with resected non-small cell lung cancer

From: Predicting bone metastasis-free survival in non-small cell lung cancer from preoperative CT via deep learning

 

Univariate

Multivariate

Variable

HR

95%CI

P-value

HR

95%CI

P-value

Gender

0.74

0.54-1.04

0.08

   

Age

1.01

0.99-1.03

0.372

   

Clinical T category

1.91

1.64-2.22

<0.001*

1.38

1.11-1.70

0.003*

Clinical N category

3.74

2.69-5.2

<0.001*

1.51

1.01-2.26

0.044*

Smoking

1.37

0.99-1.89

0.06

   

Pathologic type

1.36

1.02-1.82

0.035*

1.17

0.77-1.77

0.460

CEA (ng/mL)

2.17

1.79-2.63

<0.001*

1.31

1.05-1.64

0.016*

CYFRA21-1(ng/mL)

1.01

1.00-1.01

0.001*

1.00

1.00-1.01

0.187

Location

1.80

1.27-2.55

0.001*

1.50

0.98-2.29

0.064

Nodule type

0.41

0.29-0.58

<0.001*

0.88

0.59-1.31

0.524

Margin

1.61

1.17-2.23

0.004*

1.41

0.91-2.19

0.126

Lobulation

1.79

1.28-2.51

0.001*

1.01

0.66-1.53

0.966

Spiculation

2.42

1.75-3.34

<0.001*

2.20

1.52-3.20

<0.001*

Air bronchogram

1.33

1.14-1.55

<0.001*

1.00

0.84-1.19

0.968

Pleural attachment

1.68

1.36-2.07

<0.001*

1.29

1.04-1.59

0.021*

Postoperative treatment

1.83

1.59-2.11

<0.001*

1.33

1.11-1.59

0.002*

  1. HR hazard ratio, CI confidence interval.
  2. *P-value less than 0.05.