Fig. 6: DNA-PKc governing TH and TC differentiation. | npj Precision Oncology

Fig. 6: DNA-PKc governing TH and TC differentiation.

From: Secrets of DNA-PKcs beyond DNA repair

Fig. 6

a In naive CD4+ TH cells, upon TCR activation DNA-PKcs stimulates the expression of two key transcription factors T-bet and GATA3 which play pivotal roles in TH1 and TH2 differentiation respectively. b In naive CD4+ TH and CD8+ TC cells, upon TCR activation DNA-PKcs induces expression of CD69 and CD25 along with IFNγ, ultimately promoting activation of T cells and differentiation of CD8+ TC cells into cytotoxic T cells. Figures created with BioRender.com.

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