Table 1 Summary of survival cassette designs used in K562 armoring tests

From: A synthetic cytotoxic T cell platform for rapidly prototyping TCR function

Name

Cassette configuration

Survival1

BCL2-P2A-XIAP-T2A-MCL1

Survival2

XIAP-P2A-BCL2-IRES(VCIP)-tCD34-T2A-MCL1

Survival3

XIAP-P2A-BCL2-IRES(ECMV)-tCD34-T2A-MCL1

  1. Schematic description of gene-coding sequences inserted between lentiviral packaging elements of host transfer plasmid. All cassettes were placed under a constitutive MNDU3 promoter.
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