Fig. 4: Response to implemented treatment.

a Modified swimmer plot showing a patient-based treatment course and follow-up period. Time is given in days. The tumor entity is shown as a rectangle in a color code provided in the legend within the figure panel. The colored dot for each case represents the best response. Dark blue bars indicate the time of treatment with recommended therapy. Light blue bars indicate time without recommended treatment. Gray bars indicate discontinuation of the recommended treatment. Patients with a black triangle at the end of the bar are still being followed up. Patients with a black bar have died. MRIs during disease progression are shown with a triangle. The color is chosen according to the remission status as stated in the legend within the figure panel. Black triangles above the bars indicate the dose reduction of the recommended therapy. One patient was lost to follow-up immediately after starting treatment. No follow-up data is available for this patient. LFU loss to follow-up, wt wildtype, mut mutated, codel co-deleted, PD progressive disease, SD stable disease, PR partial remission. b Disease control rate (DCR) and overall response rate (ORR) achieved by recommended therapies among different CNS-WHO Grades. c DCR and ORR achieved by recommended therapies among different NCT evidence levels (m1 vs. m2/3).