Fig. 8: Workflow of this study. | npj Precision Oncology

Fig. 8: Workflow of this study.

From: Single cell analysis revealed SFRP2 cancer associated fibroblasts drive tumorigenesis in head and neck squamous cell carcinoma

Fig. 8

We crafted Fig. 8 utilizing Adobe Illustrator 2023 and Servier Medical Art (https://smart.servier.com). The picture unveiled the presence of SFRP2_CAFs in HNSCC, which secrete CCL2 to recruit SPP1_TAMs. These interactions are mediated by MIF-CD74, thereby facilitating tumor invasion, metastasis, apoptosis resistance and immune evasion. The transcription factor NFIX is identified as a key regulatory factor for SFRP2_CAFs.

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